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Anabolic Aid from the Past Phosphatidylserine
by preist943, IronLife.com Staff Writer & Senior Mod @ www.IronLife.com
Cortisol is the most feared hormone for bodybuilders. It’s a powerful catabolic stress hormone that among other actions cannibalizes muscle tissue. The worst effects most people don’t know, like the breakdown of connective tissues, lowered immunity, reduced muscle RNA synthesis and above all else accelerate the aging process. Makes you kind of wonder why in the Hell the body would produce such a thing well, when the body is stressed it triggers the fight or flight mechanism, which will shoot cortisol threw the roof. The hormone mobilizes the body for action for emergency fuel and reduce swelling in the event of a possible injury. When we train hard causing trauma to muscle the body believes its in danger and will release cortisol.
 High cortisol levels will impair entry of amino acids into muscle cells. Injectable testosterone will over take this hormone and increased the anabolic state but, your not stopping cortisol your just increasing the anabolic end over the catabolic state. To the hard training bber looking to get massive a post workout slin shot of at least 10 ius will further increase the anabolic state and nock cortisol on its ass but, what about the rest of the time we cant just go around doing slin all day can we.
Well there is a supplement that can block cortisol and I have no idea why it hasn’t caught on. There was plenty of research going on about it in the 80s that was very promising it was even given to patients after surgery its phosphatidylserine or PS for short don’t believe me type it in a search on yahoo or what ever and you will get a ton of links. PS is a natural occurring pholipid found in cell membranes. PS in the body is highest in the teenage years. I have read studies that show when giving PS to older adults it will improve memory, sharpen attention and even reduce depression. I believe a cortisol increase after a cycle is over to be key in some peoples depression when coming off.
PS seems to inhibit the hypothalamus pituitary adrenal axis response to stress which in turn means less cortisol release after a workout. When I searched for studies on the net I found one that was very surprising it was from a Dr in Italy that in 1992 gave oral PS to 10 bike riders another 10 received a placebo after 1hr of cycling cortisol levels was tested in the blood they found the group taking PS had 30% less cortisol than the placebo group.
Here is an overview of what PS will do and some studies you can checkout yourself :
Phosphatidylserine prevents the decline in Learning capacity that occurs with age.
Phosphatidylserine prevents the decline in the number of brain dendrites that occurs with age.
Phosphatidylserine improves Mood (especially in elderly persons.)
Phosphatidylserine is involved in Myelin Sheath repair.
Phosphatidylserine increases the number of neurotransmitter receptor sites.
Phosphatidylserine stimulates release of the brain neurotransmitter Dopamine.
Phosphatidylserine improves Reflexes [as judged by flicker-fusion response time.
Phosphatidylserine counteracts Cortisol that rises during intensive exercise and during stress.
Phosphatidylserine enhances the function of Nerve Growth Factor (NGF).
Phosphatidylserine increases production of the brain neurotransmitter acetylcholine.
Phosphatidylserine enhances brain glucose metabolism.
Is this a wonder drug no but it is very useful the main dosage is 100mg given 3x a day. I have found it really comes down to bodyweight and the amount of stress placed on the body 500-800mg before a workout works well to suppress cortisol and when coming off cycle 200-300mg given 2x a day is what I take for 4 weeks. It might not work for everyone but please give it a try just for the depression benefit alone its worth it. Off cycle depression is just the worst and, it seems this is a forgotten product. If you decide to give it a try please stop by ironlife and post your thoughts in the bodybuilding forum I would love to hear from you.
References
- Crook, T. H., et al. Effects of phosphatidylserine in age-associated memory impairment. Neurology. 41(5):644-649, 1991.
- Villardita, C., et al. Multicentre clinical trial of brain phosphatidylserine in elderly subjects with mental deterioration. Clinical Trials Journal. 24:84-93, 1987.
- Crook, T., et al. Effects of phosphatidylserine in Alzheimer's. Psychopharmacol Bull. 28:61-66, 1992
- Fungfield, E. W., et al. Double-blind study with phosphatidlyserine (PS) in Parkinsonian patients with senile dementia of Alzheimer's type (SDAT). Prog Clin Biol Res. 317:1235-1246, 1989.
- Amaducci, L. Phosphatidylserine in the dosing of Alzheimer's disease: results of a multicenter study. Psychopharmacology Bulletin. 24:130-134, 1988.
- Fungfield, E. W., et al. Double-blind study with phosphatidlyserine (PS) in parkinsonian patients with senile dementia of Alzheimer's type (SDAT). Prog Clin Biol Res. 317:1235-1246, 1989.
- Delwaide, P. J., et al. Double-blind randomized controlled study of phosphatidylserine in senile demented patients. Acta Neurol Scandinavia. 73:136-140, 1986.
- Amaducci, L., et al. Use of phosphatidylserine in Alzheimer's disease. Annals of the New York Academy of Sciences (USA). 640:245-249, 1991.
- Engel, R. R., et al. Double-blind cross-over study of phosphatidylserine vs. placebo in patients with early dementia of the Alzheimer type. Eur Neuropsychopharmacol. 2:149-155, 1992.
- Palmieri, G., et al. Double-blind controlled trial of phosphatidylserine in patients with senile mental deterioration. Clinical Trials Journal (UK). 24(1):73-83, 1987
- Gindin, J, et al. The Effect of plant phosphatidylserine on age-associated memory impairment and mood in the functioning elderly. Geriatric Institute for Education and Research, and Department of Geriatrics, Kaplan Hospital, Rehovot, Israel. 1995.
* Article by preist943, IronLife.com Staff Writer & Senior Mod @ www.IronLife.com.
* Back to This Issue's Frontpage
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